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VDAC2 Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. Interacts with hexokinases. Expressed in all tissues examined. Belongs to the eukaryotic mitochondrial porin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 10q22.2
Cellular Component: mitochondrion; nucleus
Molecular Function: protein binding; voltage-gated anion channel activity
Biological Process: anion transport
Reference #:  P45880 (UniProtKB)
Alt. Names/Synonyms: FLJ23841; hVDAC2; Outer mitochondrial membrane protein porin 2; VDAC-2; VDAC2; voltage-dependent anion channel 2; Voltage-dependent anion-selective channel protein 2
Gene Symbols: VDAC2
Molecular weight: 31,566 Da
Basal Isoelectric point: 7.5  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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