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Protein Page:

LIG1 is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC; Ligase
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: intracellular membrane-bound organelle; mitochondrion; nucleoplasm; nucleus
Molecular Function: DNA ligase (ATP) activity; DNA ligase activity
Biological Process: anatomical structure morphogenesis; base-excision repair; DNA ligation; DNA ligation during DNA repair; DNA metabolic process; DNA repair; mismatch repair; nucleotide-excision repair, DNA gap filling; transcription-coupled nucleotide-excision repair; V(D)J recombination
Reference #:  P18858 (UniProtKB)
Alt. Names/Synonyms: DNA ligase 1; DNA ligase I; DNLI1; LIG1; ligase I, DNA, ATP-dependent; MGC117397; MGC130025; Polydeoxyribonucleotide synthase [ATP] 1; polydeoxyribonucleotide synthase ATP 1
Gene Symbols: LIG1
Molecular weight: 101,736 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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