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CtIP a transcription factor containing C2H2 zinc fingers. May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein. Abundantly expressed in brain and the immune system and associated with immune system malignancies. Ionizing radiation induces its hyperphosphorylation and dissociation from BRCA1 in an ATM-dependent manner. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.-.-; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function: damaged DNA binding; protein binding; single-stranded DNA specific endodeoxyribonuclease activity
Biological Process: cell cycle checkpoint; DNA double-strand break processing; DNA repair; DNA replication; DNA synthesis during DNA repair; double-strand break repair via homologous recombination; G2/M transition DNA damage checkpoint; nucleotide-excision repair; regulation of transcription from RNA polymerase II promoter; strand displacement
Disease: Jawad Syndrome; Seckel Syndrome 2
Reference #:  Q99708 (UniProtKB)
Alt. Names/Synonyms: CtBP-interacting protein; CTIP; RBBP-8; RBBP8; retinoblastoma binding protein 8; Retinoblastoma-binding protein 8; retinoblastoma-interacting myosin-like; Retinoblastoma-interacting protein and myosin-like; RIM
Gene Symbols: RBBP8
Molecular weight: 101,942 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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