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GLUD1 May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. Homohexamer. Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC; Energy Metabolism - nitrogen; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Oxidoreductase
Chromosomal Location of Human Ortholog: 10q23.2
Cellular Component: cytoplasm; mitochondrial matrix; mitochondrion
Molecular Function: ADP binding; glutamate dehydrogenase [NAD(P)+] activity; glutamate dehydrogenase activity; GTP binding; identical protein binding; protein binding
Biological Process: amino acid biosynthetic process; glutamate biosynthetic process; glutamate catabolic process; glutamine metabolic process; mitochondrion organization and biogenesis; positive regulation of insulin secretion; substantia nigra development
Disease: Hyperinsulinemic Hypoglycemia, Familial, 6
Reference #:  P00367 (UniProtKB)
Alt. Names/Synonyms: DHE3; GDH; GDH 1; GDH1; GLUD; GLUD1; glutamate dehydrogenase (NAD(P)+); glutamate dehydrogenase 1; Glutamate dehydrogenase 1, mitochondrial; MGC132003
Gene Symbols: GLUD1
Molecular weight: 61,398 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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