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Protein Page:

FBL Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Interacts with NOLC1. Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles that contain NHP2L1, FBL, NOP5 and NOP56, plus a guide RNA. It is associated with the U3, U8, U13, X and Y small nuclear RNAs. Component of several ribosomal and nucleolar protein complexes. Interacts with PRMT5 and UTP20. Interacts with DDX5. Belongs to the methyltransferase superfamily. Fibrillarin family. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.-; Methyltransferase; Nucleolus; RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: Cajal body; fibrillar center; membrane; nucleolus; nucleoplasm; nucleus; small subunit processome
Molecular Function: ATPase binding; protein binding; RNA binding; rRNA methyltransferase activity
Biological Process: box C/D snoRNA 3'-end processing; osteoblast differentiation; rRNA methylation; rRNA processing; snoRNA localization
Reference #:  P22087 (UniProtKB)
Alt. Names/Synonyms: 34 kDa nucleolar scleroderma antigen; 34-kD nucleolar scleroderma antigen; FBL; FBRL; FIB; FIB1; fibrillarin; FLRN; RNA, U3 small nucleolar interacting protein 1; RNU3IP1; rRNA 2'-O-methyltransferase fibrillarin
Gene Symbols: FBL
Molecular weight: 33,784 Da
Basal Isoelectric point: 10.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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