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CRMP-2 a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)). Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8p21.2
Cellular Component: cytosol; membrane; microtubule; plasma membrane
Molecular Function: dihydropyrimidinase activity; identical protein binding; protein binding
Biological Process: cytoskeleton organization and biogenesis; endocytosis; nervous system development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; signal transduction
Reference #:  Q16555 (UniProtKB)
Alt. Names/Synonyms: Collapsin response mediator protein 2; collapsin response mediator protein hCRMP-2; CRMP-2; CRMP2; DHPRP2; dihydropyrimidinase-like 2; dihydropyrimidinase-like 2 long form; Dihydropyrimidinase-related protein 2; DPYL2; DPYSL2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2; Unc-33-like phosphoprotein 2
Gene Symbols: DPYSL2
Molecular weight: 62,294 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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