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Sialoprotein-2 Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component: extracellular matrix; extracellular region; extracellular space; membrane; vesicle
Molecular Function: integrin binding
Biological Process: cell adhesion; extracellular matrix organization and biogenesis; osteoblast differentiation; positive regulation of cell adhesion
Reference #:  P21815 (UniProtKB)
Alt. Names/Synonyms: BNSP; Bone sialoprotein 2; Bone sialoprotein II; BSP; BSP II; BSP-II; Cell-binding sialoprotein; IBSP; Integrin-binding sialoprotein; SIAL; SP-II
Gene Symbols: IBSP
Molecular weight: 35,148 Da
Basal Isoelectric point: 4.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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