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Cofilin-1 a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: cytoplasm; extracellular matrix; extracellular space; focal adhesion; membrane; nucleus; vesicle
Molecular Function: actin filament binding; protein binding
Biological Process: actin cytoskeleton organization and biogenesis; actin filament depolymerization; cytoskeleton organization and biogenesis; negative regulation of apoptosis; regulation of cell morphogenesis; response to virus; Rho protein signal transduction
Reference #:  P23528 (UniProtKB)
Alt. Names/Synonyms: CFL; CFL1; COF1; cofilin 1 (non-muscle); Cofilin, non-muscle isoform; Cofilin-1; p18
Gene Symbols: CFL1
Molecular weight: 18,502 Da
Basal Isoelectric point: 8.22  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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