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Myc a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors.. Seems to activate the transcription of growth-related genes. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleolus; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 8q24.21
Cellular Component: cytosol; nucleolus; nucleoplasm; nucleus; protein complex
Molecular Function: DNA binding; protein binding; protein complex binding; transcription activator binding; transcription factor activity; transcription factor binding
Biological Process: cell cycle arrest; cellular iron ion homeostasis; chromatin remodeling; chromosome organization and biogenesis; G1/S transition of mitotic cell cycle; MAPKKK cascade; negative regulation of apoptosis; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; positive regulation of caspase activity; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of telomerase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein deubiquitination; protein-DNA complex disassembly; regulation of gene expression; regulation of telomere maintenance; regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; response to drug; response to gamma radiation; ureteric bud branching; Wnt receptor signaling pathway through beta-catenin
Disease: Burkitt Lymphoma
Reference #:  P01106 (UniProtKB)
Alt. Names/Synonyms: avian myelocytomatosis viral oncogene homolog; BHLHE39; c-Myc; Class E basic helix-loop-helix protein 39; MRTL; MYC; Myc proto-oncogene protein; myc-related translation/localization regulatory factor; Proto-oncogene c-Myc; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog (avian)
Gene Symbols: MYC
Molecular weight: 48,804 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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