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KHSRP an RNA binding and processing protein that binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3' untranslated regions, possibly by recruiting degradation machinery to ARE-containing mRNAs. Interacts with APC which is part of the apolipoprotein B mRNA editing enzyme complex. The interaction is not required for activity of the catalytic component, APOBEC1, but may confer stability on the complex. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytosol; membrane; nucleoplasm
Molecular Function: protein binding; RNA binding
Biological Process: negative regulation of nitric oxide biosynthetic process; regulation of mRNA stability; RNA splicing; RNA splicing, via transesterification reactions
Reference #:  Q92945 (UniProtKB)
Alt. Names/Synonyms: Far upstream element-binding protein 2; FBP2; FUBP2; FUSE binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KH-type splicing regulatory protein; KHSRP; KSRP; MGC99676; p75
Gene Symbols: KHSRP
Molecular weight: 73,115 Da
Basal Isoelectric point: 6.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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