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CLTC a major protein component of the cytoplasmic face of coated vesicles and coated pits. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 17q23.1
Cellular Component: clathrin coat; clathrin-coated vesicle; cytosol; endosome; extracellular matrix; focal adhesion; lysosome; membrane; plasma membrane; protein complex; spindle; trans-Golgi network membrane
Molecular Function: clathrin light chain binding; double-stranded RNA binding; low-density lipoprotein receptor binding; protein binding; protein kinase binding; RNA binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; clathrin cage assembly; low-density lipoprotein receptor catabolic process; microtubule-based movement; mitotic cell cycle; osteoblast differentiation; receptor internalization; receptor-mediated endocytosis; retrograde transport, endosome to Golgi; transcytosis; transferrin transport; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  Q00610 (UniProtKB)
Alt. Names/Synonyms: CHC; CHC17; Clathrin heavy chain 1; Clathrin heavy chain on chromosome 17; clathrin, heavy chain (Hc); clathrin, heavy polypeptide (Hc); clathrin, heavy polypeptide-like 2; CLH-17; CLH1; CLH17; CLTC; CLTCL2; Hc; KIAA0034
Gene Symbols: CLTC
Molecular weight: 191,615 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.
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