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APRIN a widely expressed nuclear protein. Is lost in many cancers and may function as a tumor suppressor. Correlates with differentiation in embryonal carcinoma stem cells; its knockdown disrupted Nanog, Oct4, and SOX2 regulation. Plays a role in androgen-induced proliferative arrest in prostate cells. Is upregulated in androgen-sensitive LNCaP prostate cancer cells undergoing androgen-induced proliferative block. Required for maintenance of sister chromatid cohesion during mitosis. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Belongs to the PDS5 family. Induced by the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Phosphorylated upon DNA damage. Maximum levels occur 18-20 hours after androgen exposure. Interacts with the cohesin complex. Phosphorylated upon DNA damage, probably by ATM or ATR. Five isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding
Chromosomal Location of Human Ortholog: 12p12
Cellular Component: chromatin; nucleoplasm; nucleus
Molecular Function: DNA binding
Biological Process: DNA repair; mitotic sister chromatid cohesion; negative regulation of cell proliferation; regulation of cell proliferation
Reference #:  Q6TRW4 (UniProtKB)
Alt. Names/Synonyms: Androgen-induced proliferation inhibitor; androgen-induced prostate proliferative shutoff associated protein; Androgen-induced prostate proliferative shutoff-associated protein AS3; androgen-induced shutoff 3; Aprin; As3; CG008; FLJ23236; KIAA0979; PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae); Pds5b; Sister chromatid cohesion protein PDS5 homolog B
Gene Symbols: Pds5b
Molecular weight: 164,459 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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