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Jun the protooncogene c-Jun is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The Jun Kinases (JNKs) binds to the N-terminal region of c-Jun and phosphorylate it in response to extracellular signals including growth factors, cytokines and stress, regulating its transcriptional activity. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 1p32.1
Cellular Component: nuclear chromosome; nucleoplasm; nucleus
Molecular Function: DNA binding; enzyme binding; GTPase activator activity; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA binding; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: cellular response to hormone stimulus; negative regulation of DNA binding; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; regulation of cell cycle; regulation of cell proliferation; regulation of transcription factor activity; response to cAMP; response to cytokine stimulus; response to drug; response to lipopolysaccharide; response to mechanical stimulus; response to radiation; SMAD protein nuclear translocation; transforming growth factor beta receptor signaling pathway
Reference #:  P05412 (UniProtKB)
Alt. Names/Synonyms: Activator protein 1; AP-1; AP1; c-Jun; enhancer-binding protein AP1; JUN; Jun activation domain binding protein; jun oncogene; p39; Proto-oncogene c-Jun; Transcription factor AP-1; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog
Gene Symbols: JUN
Molecular weight: 35,676 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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