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IL3 Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; Cytokine; Oncoprotein; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11 B1.3|11 32.13 cM
Cellular Component: extracellular space
Molecular Function: cytokine activity; growth factor activity; interleukin-1 receptor binding; interleukin-3 receptor binding
Biological Process: activation of JAK protein; cytokine and chemokine mediated signaling pathway; fever; hemopoiesis; monocyte differentiation; myeloid cell apoptosis; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of mast cell apoptosis; positive regulation of cell proliferation; positive regulation of JNK cascade; positive regulation of myeloid leukocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; regulation of cell growth; regulation of gene expression; regulation of glycolysis; regulation of protein amino acid dephosphorylation; response to hormone stimulus; response to hypoxia
Reference #:  P01586 (UniProtKB)
Alt. Names/Synonyms: BPA; Csfmu; HCGF; Hematopoietic growth factor; IL-3; Il3; interleukin 3; Interleukin-3; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; OTTMUSP00000005831; P-cell-stimulating factor; PSF
Gene Symbols: Il3
Molecular weight: 18,540 Da
Basal Isoelectric point: 8.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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