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GRP78 a member of the HSP family of molecular chaperones required for endoplasmic reticulum integrity and stress-induced autophagy. Plays a central role in regulating the unfolded protein response (UPR), and is an obligatory component of autophagy in mammalian cells.. May play an important role in cellular adaptation and oncogenic survival. One of the client proteins of GRP78 is protein double-stranded RNA-activated protein-like endoplasmic reticulum kinase (PERK). Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of Human Ortholog: 9q33.3
Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; ER-Golgi intermediate compartment; extracellular matrix; focal adhesion; integral to endoplasmic reticulum membrane; membrane; midbody; nucleus; protein complex; signalosome
Molecular Function: ATPase activity; cadherin binding; calcium ion binding; chaperone binding; enzyme binding; glycoprotein binding; misfolded protein binding; protein binding; protein domain specific binding; ubiquitin protein ligase binding; unfolded protein binding
Biological Process: cellular response to glucose starvation; ER-associated protein catabolic process; negative regulation of apoptosis; positive regulation of cell migration; substantia nigra development; unfolded protein response
Reference #:  P11021 (UniProtKB)
Alt. Names/Synonyms: 78 kDa glucose-regulated protein; BiP; Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; FLJ26106; GRP-78; GRP78; Heat shock 70 kDa protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD); HSPA5; Immunoglobulin heavy chain-binding protein; MIF2
Gene Symbols: HSPA5
Molecular weight: 72,333 Da
Basal Isoelectric point: 5.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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