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PBX1 Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Forms a heterodimer with MEIS1 which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Interacts with PBXIP1. Expressed in all tissues except in cells of the B and T lineage. Belongs to the TALE/PBX homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding
Biological Process: somatic stem cell maintenance
Reference #:  P40424 (UniProtKB)
Alt. Names/Synonyms: DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; PBX1; Pre-B cell leukemia transcription factor-1; pre-B-cell leukemia homeobox 1; Pre-B-cell leukemia transcription factor 1; PRL
Gene Symbols: PBX1
Molecular weight: 46,626 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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