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BIK accelerates programmed cell death. Binding to the apoptosis repressors Bcl-xL, Bcl-2, or BHRF1 (the Epstein-Barr virus homolog of Bcl-2) suppresses its death-promoting activity. Contains 1 Bcl-2 homology 3 (BH3) domain. Does not interact with Bax. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 22q13.2
Molecular Function: protein binding
Biological Process: apoptosis; male gonad development; positive regulation of protein homooligomerization
Reference #:  Q13323 (UniProtKB)
Alt. Names/Synonyms: Apoptosis inducer NBK; apoptosis-inducing NBK; Bcl-2-interacting killer; BCL2-interacting killer (apoptosis-inducing); BIK; BIP1; BP4; NBK
Gene Symbols: BIK
Molecular weight: 18,016 Da
Basal Isoelectric point: 4.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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