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Bcr a protein with serine/threonine protein kinase activity and is a GTPase-activating protein (GAP) for RAC1 and CDC42. The amino-terminal region of Bcr contains an oligomerization domain, a serine/threonine kinase domain and a region that binds SH2 domains. The middle of the protein has a PH domain and a region of sequence similarity to the guanine nucleotide exchange factors for the Rho family of GTP binding proteins. The carboxy-terminal region promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. A breakpoint cluster region protein that participates in a t(9;22)(q34;q11) chromosomal translocation that produces a BCR-ABL oncogene responsible for chronic myeloid leukemia (CML), acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The function of wild type Bcr in cells remains unclear. PDGF receptor may use Bcr as a downstream signaling mediator. Tyr177 of human Bcr, phosphorylated in the Bcr-Abl fusion protein, provides a docking site for Gab2 and GRB2, and is important in the transforming activity of Bcr-Abl. Sequence variants of the Bcr protein may be associated with bipolar disorder. Two alternatively spliced isoforms of the human protein have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; BCR family; EC; GAP; GAP, Rac/Rho; GEF, Rac/Rho; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: cell junction; cytosol; extracellular exosome; membrane; postsynaptic density; postsynaptic membrane; protein complex
Molecular Function: ATP binding; GTPase activator activity; kinase activity; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; Rho guanyl-nucleotide exchange factor activity
Biological Process: actin cytoskeleton organization; brain development; homeostasis of number of cells; inner ear morphogenesis; intracellular protein transmembrane transport; negative regulation of cellular extravasation; negative regulation of inflammatory response; negative regulation of neutrophil degranulation; negative regulation of reactive oxygen species metabolic process; neuromuscular process controlling balance; peptidyl-tyrosine phosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of GTPase activity; positive regulation of phagocytosis; protein amino acid phosphorylation; protein autophosphorylation; regulation of cell cycle; regulation of nitrogen compound metabolic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; regulation of vascular permeability; renal system process; signal transduction
Disease: Leukemia, Acute Lymphoblastic; Leukemia, Chronic Myeloid
Reference #:  P11274 (UniProtKB)
Alt. Names/Synonyms: ALL; BCR; BCR1; breakpoint cluster region; Breakpoint cluster region protein; CML; D22S11; D22S662; FLJ16453; PHL; Renal carcinoma antigen NY-REN-26
Gene Symbols: BCR
Molecular weight: 142,819 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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