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DPYD Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. Homodimer. Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells. Belongs to the dihydropyrimidine dehydrogenase family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: 1p21.3
Cellular Component: cytoplasm; cytosol
Molecular Function: dihydropyrimidine dehydrogenase (NADP+) activity; FAD binding; NADP binding; protein binding; protein homodimerization activity
Biological Process: purine base catabolic process; pyrimidine base catabolic process; pyrimidine nucleoside catabolic process; thymidine catabolic process; thymine catabolic process; uracil catabolic process
Disease: Dihydropyrimidine Dehydrogenase Deficiency
Reference #:  Q12882 (UniProtKB)
Alt. Names/Synonyms: DHP; DHPDHase; dihydropyrimidine dehydrogenase; Dihydropyrimidine dehydrogenase [NADP+]; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPD; DPYD; MGC132008; MGC70799
Gene Symbols: DPYD
Molecular weight: 111,401 Da
Basal Isoelectric point: 6.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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