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ACO2 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. Monomer. Belongs to the aconitase/IPM isomerase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC; Lyase; Mitochondrial
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: mitochondrial matrix; mitochondrion
Molecular Function: aconitate hydratase activity; iron ion binding
Biological Process: citrate metabolic process; generation of precursor metabolites and energy; tricarboxylic acid cycle
Disease: Infantile Cerebellar-retinal Degeneration; Optic Atrophy 8
Reference #:  Q99798 (UniProtKB)
Alt. Names/Synonyms: ACO2; ACON; Aconitase; aconitase 2, mitochondrial; Aconitate hydratase, mitochondrial; ACONM; Citrate hydro-lyase; MGC20605; MGC33908
Gene Symbols: ACO2
Molecular weight: 85,425 Da
Basal Isoelectric point: 7.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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