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RANBP1 a Ran-binding protein that functions in nuclear trafficking, mitosis, chromosomal segregation, and ciliogenesis. Controls both nuclear import and export. Contains a Ran binding domain and a C-terminal nuclear export signal. Following export from the nucleus, forms a complex with RanGTP and XPO1/cargo, leading to dissociation of cargo from XPO1. Stimulates RanGAP1 association with RanGTP, facilitating RanGTP hydrolysis to RanGDP. Stabilizes and regulates the formation of a RanGDP-importin/NLS receptor-RanBP1 complex during nuclear import. Controls RanGTP distribution along mitotic microtubules, which localizes critical factors, such as cyclin B1 and DLG7, to mitotic microtubles and regulates chromosome segregation. Knock down or overexpression experiments affect cellular ciliogenesis by regulating the local RanGTP concentation at the base of cilia.Belongs to the RANBP1 family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; G protein regulator, misc.; Microtubule-binding
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: centrosome; cytoplasm; cytosol; nuclear envelope; nucleus
Molecular Function: cadherin binding; GDP-dissociation inhibitor activity; GTPase activator activity; protein binding; Ran GTPase binding
Biological Process: G1/S transition of mitotic cell cycle; positive regulation of mitotic centrosome separation; protein import into nucleus; RNA export from nucleus; signal transduction; spindle organization and biogenesis; ubiquitin-dependent protein catabolic process; viral reproduction
Reference #:  P43487 (UniProtKB)
Alt. Names/Synonyms: HTF9A; MGC88701; RAN binding protein 1; Ran-binding protein 1; Ran-specific GTPase-activating protein; RANBP1; RANG
Gene Symbols: RANBP1
Molecular weight: 23,310 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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