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RRM2 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Belongs to the ribonucleoside diphosphate reductase small chain family. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component: cytosol; ribonucleoside-diphosphate reductase complex
Molecular Function: protein binding; ribonucleoside-diphosphate reductase activity
Biological Process: deoxyribonucleotide biosynthetic process; G1/S-specific transcription in mitotic cell cycle; nucleobase, nucleoside and nucleotide interconversion
Reference #:  P31350 (UniProtKB)
Alt. Names/Synonyms: R2; Ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase M2; ribonucleotide reductase M2 polypeptide; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; RIR2; RR2; RR2M; RRM2
Gene Symbols: RRM2
Molecular weight: 44,878 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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