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RAB5A Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p24.3
Cellular Component: axon; cell soma; clathrin coated vesicle membrane; cytoplasm; cytosol; dendrite; early endosome; early endosome membrane; endocytic vesicle; endosome; endosome membrane; nerve terminal; plasma membrane; synaptic vesicle; terminal button
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding
Biological Process: blood coagulation; early endosome to late endosome transport; endocytosis; phosphatidylinositol biosynthetic process; positive regulation of exocytosis; post-translational protein modification; regulation of endocytosis; regulation of endosome size; regulation of filopodium formation; transcytosis
Reference #:  P20339 (UniProtKB)
Alt. Names/Synonyms: RAB5; RAB5A; RAB5A, member RAS oncogene family; RAS-associated protein RAB5A; Ras-related protein Rab-5A
Gene Symbols: RAB5A
Molecular weight: 23,659 Da
Basal Isoelectric point: 8.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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