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PPP2R5D The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. By retinoic acid; in neuroblastoma cell lines. Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain. Belongs to the phosphatase 2A regulatory subunit B56 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: cytosol; nucleoplasm; nucleus
Molecular Function: protein binding; protein serine/threonine phosphatase activity
Biological Process: nervous system development
Disease: Mental Retardation, Autosomal Dominant 35
Reference #:  Q14738 (UniProtKB)
Alt. Names/Synonyms: 2A5D; B56D; MGC2134; MGC8949; PP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta; PP2A, B subunit, B' delta isoform; PP2A, B subunit, B56 delta isoform; PP2A, B subunit, PR61 delta isoform; PP2A, B subunit, R5 delta isoform; PPP2R5D; protein phosphatase 2, regulatory subunit B (B56), delta isoform; protein phosphatase 2, regulatory subunit B', delta; protein phosphatase 2, regulatory subunit B', delta isoform; Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Gene Symbols: PPP2R5D
Molecular weight: 69,992 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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