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TXNRD2 Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Mitochondrial; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; Oxidoreductase
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: cytosol; mitochondrial matrix; mitochondrion
Molecular Function: protein binding; thioredoxin-disulfide reductase activity
Biological Process: cell redox homeostasis; response to oxygen radical
Reference #:  Q9NNW7 (UniProtKB)
Alt. Names/Synonyms: KIAA1652; Selenoprotein Z; SelZ; thioredoxin reductase 2; Thioredoxin reductase 2, mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR-beta; TR3; TRXR2; TXNRD2
Gene Symbols: TXNRD2
Molecular weight: 56,507 Da
Basal Isoelectric point: 7.24  Predict pI for various phosphorylation states
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