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UBE2B a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: chromatin; cytoplasm; nucleoplasm; nucleus; replication fork
Molecular Function: protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: DNA damage response, detection of DNA damage; DNA repair; histone H2A ubiquitination; postreplication repair; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein monoubiquitination; protein polyubiquitination; protein stabilization; protein ubiquitination; response to DNA damage stimulus; response to drug; response to UV; spermatogenesis; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway through beta-catenin
Reference #:  P63146 (UniProtKB)
Alt. Names/Synonyms: E2 protein; E2-17kDa; hHR6B; HR6B; RAD6 homolog B; RAD6B; UBC2; UBE2B; Ubiquitin carrier protein B; Ubiquitin-conjugating enzyme E2 B; Ubiquitin-conjugating enzyme E2-17 kDa; ubiquitin-conjugating enzyme E2B (RAD6 homolog); Ubiquitin-protein ligase B
Gene Symbols: UBE2B
Molecular weight: 17,312 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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