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UBE2A a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: chromatin; cytoplasm; cytosol; nuclear chromatin; nucleoplasm
Molecular Function: protein binding; ubiquitin binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: DNA repair; histone H2A ubiquitination; positive regulation of cell proliferation; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein polyubiquitination; protein ubiquitination; response to UV
Disease: Mental Retardation, X-linked, Syndromic, Nascimento Type
Reference #:  P49459 (UniProtKB)
Alt. Names/Synonyms: hHR6A; HR6A; RAD6 homolog A; RAD6A; UBC2; UBE2A; Ubiquitin carrier protein A; Ubiquitin-conjugating enzyme E2 A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); Ubiquitin-protein ligase A
Gene Symbols: UBE2A
Molecular weight: 17,315 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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