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CTBP2 Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 10q26.13
Cellular Component: cytosol; nucleus; transcriptional repressor complex
Molecular Function: glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; protein binding; protein complex binding; protein homodimerization activity; protein kinase binding; transcription corepressor activity
Biological Process: negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of retinoic acid receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; viral genome replication; white fat cell differentiation
Reference #:  P56545 (UniProtKB)
Alt. Names/Synonyms: C-terminal binding protein 2; C-terminal-binding protein 2; CTBP2; ribeye
Gene Symbols: CTBP2
Molecular weight: 48,945 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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