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RICTOR a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component: cytosol; TORC2 complex
Molecular Function: enzyme activator activity; protein binding; protein kinase binding
Biological Process: actin cytoskeleton reorganization; embryonic development; establishment and/or maintenance of actin cytoskeleton polarity; establishment of cell polarity; peptidyl-serine phosphorylation; phosphoinositide-mediated signaling; positive regulation of protein kinase B signaling cascade; positive regulation of TOR signaling pathway; regulation of actin cytoskeleton organization and biogenesis; regulation of phosphorylation; regulation of protein kinase B signaling cascade; T cell costimulation
Reference #:  Q6R327 (UniProtKB)
Alt. Names/Synonyms: AVO3 homolog; DKFZp686B11164; hAVO3; KIAA1999; mAVO3; MGC39830; PIA; pianissimo; Rapamycin-insensitive companion of mTOR; RICTOR; RICTR; RPTOR independent companion of MTOR, complex 2; TORC2-specific protein AVO3
Gene Symbols: RICTOR
Molecular weight: 192,218 Da
Basal Isoelectric point: 7.22  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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