The CCR4-NOT complex functions as general transcription regulation complex. Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Belongs to the CNOT2/3/5 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Molecular Function: poly(A)-specific ribonuclease activity; protein binding
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA catabolic process, deadenylation-dependent decay; negative regulation of estrogen receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of translation; poly(A) tail shortening