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CSFR an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: cell surface; CSF1-CSF1R complex; integral component of plasma membrane; intracellular membrane-bound organelle; nucleoplasm; plasma membrane
Molecular Function: ATP binding; cytokine binding; macrophage colony-stimulating factor receptor activity; protein binding; protein homodimerization activity; protein phosphatase binding
Biological Process: axon guidance; cell proliferation; cellular response to cytokine stimulus; cytokine-mediated signaling pathway; forebrain neuron differentiation; hemopoiesis; inflammatory response; innate immune response; intercellular junction maintenance; macrophage colony-stimulating factor signaling pathway; macrophage differentiation; monocyte differentiation; multicellular organism development; negative regulation of apoptosis; negative regulation of cell proliferation; olfactory bulb development; osteoclast differentiation; peptidyl-tyrosine phosphorylation; phosphatidylinositol metabolic process; phosphoinositide-mediated signaling; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of chemokine secretion; positive regulation of ERK1 and ERK2 cascade; positive regulation of protein phosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of tyrosine phosphorylation of STAT protein; protein autophosphorylation; regulation of actin cytoskeleton reorganization; regulation of bone resorption; regulation of cell shape; ruffle organization; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Leukoencephalopathy, Diffuse Hereditary, With Spheroids
Reference #:  P07333 (UniProtKB)
Alt. Names/Synonyms: C-FMS; CD115; CD115 antigen; colony stimulating factor 1 receptor; CSF-1-R; CSF1R; CSFR; FIM2; FMS; FMS proto-oncogene; macrophage colony stimulating factor I receptor; Macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; Proto-oncogene c-Fms
Gene Symbols: CSF1R
Molecular weight: 107,984 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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