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RIP3 Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F- actin-binding region leads to disassembly of stress fibers in neuronal cells. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: actin cytoskeleton; cytosol; focal adhesion
Molecular Function: cadherin binding; protein binding
Reference #:  Q6WCQ1 (UniProtKB)
Alt. Names/Synonyms: KIAA0864; M-RIP; MPRIP; MRIP; myosin phosphatase Rho interacting protein; Myosin phosphatase Rho-interacting protein; myosin phosphatase-Rho interacting protein; p116Rip; Rho interacting protein 3; Rho-interacting protein 3; RHOIP3; RIP3
Gene Symbols: MPRIP
Molecular weight: 116,533 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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