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MYO5A Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. May also be required for some polarization process involved in dendrite formation. May be a homodimer, which associates with multiple calmodulin or myosin light chains. Binds MLPH and MYRIP. Interacts with RIPL2, the interaction is required for its role in dendrite formation. Detected in melanocytes. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 9 D|9 42.26 cM
Cellular Component: actin filament; actomyosin; actomyosin, myosin complex part; axon; cell soma; cytoplasm; cytosol; dendrite; early endosome; endoplasmic reticulum; filopodium tip; Golgi apparatus; intermediate filament; late endosome; lysosome; melanosome; membrane; myosin complex; neuron projection; peroxisome; photoreceptor outer segment; recycling endosome; ribonucleoprotein complex; ruffle; secretory granule; synaptic vesicle; unconventional myosin complex; vesicle
Molecular Function: actin binding; ATP binding; ATP-dependent protein binding; calcium ion binding; calcium-dependent protein binding; calmodulin binding; microfilament motor activity; motor activity; protein binding; protein dimerization activity; protein heterodimerization activity; protein kinase binding; Rab GTPase binding; RNA binding; SNARE binding; syntaxin-1 binding
Biological Process: actin filament-based movement; anagen; cellular response to insulin stimulus; ER localization; exocytosis; hair follicle maturation; insulin secretion; locomotion during locomotory behavior; long-chain fatty acid biosynthetic process; melanin biosynthetic process; melanin metabolic process; melanocyte differentiation; melanosome localization; melanosome transport; myelination; neuromuscular process controlling balance; odontogenesis; pigmentation; pigmentation during development; post-Golgi vesicle-mediated transport; regulation of exocytosis; regulation of inositol-1,4,5-triphosphate receptor activity; secretory granule localization; synapse organization and biogenesis; synaptic transmission; transport; vesicle transport along actin filament; vesicle-mediated transport; visual perception
Reference #:  Q99104 (UniProtKB)
Alt. Names/Synonyms: 9630007J19Rik; AI413174; AI661011; d; d-120J; Dbv; Dilute; dilute lethal-20J protein; Dilute myosin heavy chain, non-muscle; flail; flailer; flr; MVa; Myo5; Myo5a; myosin VA; Myosin-Va; MyoVA; Sev-1
Gene Symbols: Myo5a
Molecular weight: 215,538 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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