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MAP6 Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca(2+). Expressed in brain. Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study). Belongs to the STOP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 7|7 E1
Cellular Component: microtubule; perinuclear region of cytoplasm
Molecular Function: microtubule binding
Biological Process: dendrite morphogenesis; lysosome localization
Reference #:  Q7TSJ2 (UniProtKB)
Alt. Names/Synonyms: 2810411E12Rik; MAP-6; Map6; Microtubule-associated protein 6; Mtap6; Stable tubule-only polypeptide; STOP
Gene Symbols: Map6
Molecular weight: 96,450 Da
Basal Isoelectric point: 9.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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