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GTF2F1 TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2, CTDP1, TAF6/TAFII80 and URI1. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the TFIIF alpha subunit family. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC; GTF2F1 family; Kinase, protein; Transcription initiation complex
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cell junction; intracellular membrane-bound organelle; nucleoplasm; nucleus; protein complex; transcription factor TFIID complex; transcription factor TFIIF complex
Molecular Function: phosphatase activator activity; protein binding; protein domain specific binding; protein phosphatase binding; RNA binding; transcription coactivator activity; transcription factor binding
Biological Process: fibroblast growth factor receptor signaling pathway; mRNA capping; nuclear mRNA splicing, via spliceosome; positive regulation of viral transcription; response to virus; RNA elongation from RNA polymerase II promoter; RNA metabolic process; snRNA transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
Reference #:  P35269 (UniProtKB)
Alt. Names/Synonyms: BTF4; General transcription factor IIF 74 kDa subunit; General transcription factor IIF subunit 1; general transcription factor IIF, polypeptide 1, 74kDa; GTF2F1; RAP74; T2FA; TF2F1; TFIIF; TFIIF-alpha; Transcription initiation factor IIF subunit alpha; Transcription initiation factor RAP74
Gene Symbols: GTF2F1
Molecular weight: 58,240 Da
Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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