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4E-T Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism. Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Widely expressed. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Karyopherin; Nuclear import; Translation
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane; nucleus
Molecular Function: protein binding; protein transporter activity; RNA binding
Reference #:  Q9NRA8 (UniProtKB)
Alt. Names/Synonyms: 2610509L04Rik; 4E-T; 4ET; Clast4; eIF4E transporter; eIF4E-transporter; EIF4ENIF1; Eukaryotic translation initiation factor 4E nuclear import factor 1; Eukaryotic translation initiation factor 4E transporter; FLJ21601; FLJ26551
Gene Symbols: EIF4ENIF1
Molecular weight: 108,201 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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