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THEX1 RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs. Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Interacts in a cooperative manner with SLBP to the mature 3'-end of histone mRNAs. Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the stem-loop structure of the 3'-end of histone mRNAs. Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.-.-; Hydrolase; Nucleolus
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus
Molecular Function: 3'-5' exonuclease activity; 3'-5'-exoribonuclease activity; metal ion binding; protein binding; ribosome binding; rRNA binding
Biological Process: DNA metabolic process; RNA phosphodiester bond hydrolysis, exonucleolytic; RNA-mediated gene silencing; rRNA 3'-end processing; rRNA processing
Reference #:  Q8IV48 (UniProtKB)
Alt. Names/Synonyms: 3' exoribonuclease; 3'-5' exonuclease ERI1; 3'-5' exoribonuclease 1; 3'EXO; 3'HEXO; enhanced RNAi three prime mRNA exonuclease homolog 1; Eri-1 homolog; ERI1; exoribonuclease 1; HEXO; histone mRNA 3' end-specific exonuclease; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; MGC35395; Protein 3'hExo; THEX1; three prime histone mRNA exonuclease 1; three prime mRNA exonuclease 1
Gene Symbols: ERI1
Molecular weight: 40,064 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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