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KCNE1 Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Associates with KCNQ1/KVLQT1 and KCNH2/HERG. Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. Belongs to the potassium channel KCNE family. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component: apical plasma membrane; cell surface; lysosome; plasma membrane; voltage-gated potassium channel complex; Z disc
Molecular Function: delayed rectifier potassium channel activity; potassium channel regulator activity; protein binding; telethonin binding; voltage-gated potassium channel activity
Biological Process: protein amino acid N-linked glycosylation; protein amino acid O-linked glycosylation; sensory perception of sound
Disease: Jervell And Lange-nielsen Syndrome 2; Long Qt Syndrome 5
Reference #:  P15382 (UniProtKB)
Alt. Names/Synonyms: cardiac delayed rectifier potassium channel protein; Delayed rectifier potassium channel subunit IsK; FLJ18426; FLJ38123; FLJ94103; IKs producing slow voltage-gated potassium channel subunit beta Mink; ISK; JLNS; JLNS2; KCNE1; LQT2/5; LQT5; MGC33114; Minimal potassium channel; MinK; Potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; voltage gated potassiun channel accessory subunit
Gene Symbols: KCNE1
Molecular weight: 14,675 Da
Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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