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NT-3 Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: cytoplasmic vesicle; extracellular region
Molecular Function: chemoattractant activity; growth factor activity; neurotrophin p75 receptor binding; receptor binding
Biological Process: activation of MAPK activity; activation of protein kinase B; cell-cell signaling; induction of positive chemotaxis; negative regulation of neuron apoptosis; negative regulation of peptidyl-tyrosine phosphorylation; nervous system development; neurite morphogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization; regulation of apoptosis; regulation of neuron differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P20783 (UniProtKB)
Alt. Names/Synonyms: HDNF; MGC129711; Nerve growth factor 2; neurotrophin 3; Neurotrophin-3; NGF-2; NGF2; NT-3; NT3; NTF3
Gene Symbols: NTF3
Molecular weight: 29,355 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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