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GGA3 Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Monomer. Interacts with SORT1, SORL1, LRP3, GGA binding partner (GGABP) and P200. Interacts with GGA1 and GGA2. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the membrane proteins M6PR/CD-MPR, IGF2R/CI-MPR and BACE1 and the accessory proteins SYNRG, EPN4, NECAP1, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC. Ubiquitously expressed. Belongs to the GGA protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: early endosome membrane; endosome membrane; Golgi apparatus; recycling endosome membrane; trans-Golgi network
Molecular Function: ADP-ribosylation factor binding; protein binding
Biological Process: cellular protein metabolic process
Reference #:  Q9NZ52 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosylation factor-binding protein GGA3; GGA3; golgi associated, gamma adaptin ear containing, ARF binding protein 3; golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Golgi-localized, gamma ear-containing, ARF-binding protein 3; KIAA0154
Gene Symbols: GGA3
Molecular weight: 78,315 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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