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CASP2 Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Protease
Chromosomal Location of Human Ortholog: 7q34
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: cysteine-type endopeptidase activity; enzyme binding; identical protein binding; protein binding; protein domain specific binding
Biological Process: caspase activation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of apoptosis; protein processing; regulation of apoptosis
Reference #:  P42575 (UniProtKB)
Alt. Names/Synonyms: CASP-2; CASP2; caspase 2, apoptosis-related cysteine peptidase; Caspase-2; Caspase-2 subunit p12; Caspase-2 subunit p13; Caspase-2 subunit p18; ICH-1 protease; ICH-1L; ICH-1L/1S; ICH1; NEDD-2; NEDD2; NEDD2 apoptosis regulatory; Neural precursor cell expressed developmentally down-regulated protein 2; neural precursor cell expressed, developmentally down-regulated 2; Protease ICH-1
Gene Symbols: CASP2
Molecular weight: 50,685 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  ErbB/HER Signaling  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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