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Fer a non-receptor tyrosine kinase of the Fer family. Regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Increased expression associated with prostate cancer proliferation, and antisense blocks soft agar growth. Note: This description may include information from UniProtKB.
Protein type: EC; Fer family; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 5q21.3
Cellular Component: actin cytoskeleton; cell junction; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; lamellipodium; microtubule cytoskeleton; nuclear chromatin; nucleus
Molecular Function: epidermal growth factor receptor binding; lipid binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity
Biological Process: actin cytoskeleton reorganization; activation of NF-kappaB transcription factor; cell adhesion; cell differentiation; cell proliferation; cellular response to insulin stimulus; chemotaxis; cytokine and chemokine mediated signaling pathway; diapedesis; innate immune response; microtubule cytoskeleton organization and biogenesis; mitotic cell cycle; negative regulation of mast cell activation during immune response; peptidyl-tyrosine phosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of cell proliferation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of epidermal growth factor receptor signaling pathway; regulation of mast cell degranulation; regulation of protein amino acid phosphorylation; response to lipopolysaccharide; tyrosine phosphorylation of STAT protein
Reference #:  P16591 (UniProtKB)
Alt. Names/Synonyms: FER; fer (fps/fes related) tyrosine kinase; p94-Fer; phosphoprotein NCP94; Proto-oncogene c-Fer; TYK3; Tyrosine kinase 3; Tyrosine-protein kinase Fer
Gene Symbols: FER
Molecular weight: 94,638 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates  |  Wnt/ß-Catenin Signaling
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