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TEC a non-receptor protein-tyrosine kinases of the Tec family. Containing a pleckstrin homology domain. Involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. May be an important signal transducer for cell division and/or for differentiation in the liver system. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family
Chromosomal Location of Human Ortholog: 4p12-p11
Cellular Component: cytoskeleton; cytosol; extrinsic to internal side of plasma membrane; plasma membrane
Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; receptor binding
Biological Process: B cell receptor signaling pathway; cell differentiation; innate immune response; integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; tissue regeneration; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P42680 (UniProtKB)
Alt. Names/Synonyms: MGC126760; MGC126762; PSCTK4; TEC; tec protein tyrosine kinase; Tyrosine-protein kinase Tec
Gene Symbols: TEC
Molecular weight: 73,581 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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