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Etk a tyrosine kinase of the Tec family. Activity is required for IL6-induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family
Chromosomal Location of Human Ortholog: Xp22.2
Cellular Component: cytosol; extrinsic to internal side of plasma membrane; nucleoplasm; plasma membrane
Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding; signal transducer activity
Biological Process: innate immune response; mesoderm development; NK T cell differentiation; phosphatidylinositol biosynthetic process; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P51813 (UniProtKB)
Alt. Names/Synonyms: BMX; BMX non-receptor tyrosine kinase; Bone marrow tyrosine kinase gene in chromosome X protein; Cytoplasmic tyrosine-protein kinase BMX; Epithelial and endothelial tyrosine kinase; ETK; Etk/Bmx cytosolic tyrosine kinase; NTK38; NTK38 tyrosine kinase; PSCTK2; PSCTK3
Gene Symbols: BMX
Molecular weight: 78,011 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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