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MEKK3 a protein kinase of the STE11 family. Phosphorylated and activated by MLK3 and TAK1. Phosphorylates and activates MEK5. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein amino acid autophosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; stress-activated protein kinase signaling pathway
Reference #:  Q99759 (UniProtKB)
Alt. Names/Synonyms: M3K3; MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; MEKK3; Mitogen-activated protein kinase kinase kinase 3
Gene Symbols: MAP3K3
Molecular weight: 70,898 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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