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IFNG Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Membrane protein, integral; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: extracellular region; extracellular space
Molecular Function: cytokine activity
Biological Process: adaptive immune response; apoptosis; cell cycle arrest; cell motility; cell surface receptor linked signal transduction; humoral immune response; negative regulation of epithelial cell differentiation; negative regulation of interleukin-17 production; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of autophagy; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response; positive regulation of cell proliferation; positive regulation of interleukin-12 production; positive regulation of interleukin-23 production; positive regulation of killing of cells of another organism; positive regulation of membrane protein ectodomain proteolysis; positive regulation of nitric oxide biosynthetic process; positive regulation of osteoclast differentiation; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of protein amino acid phosphorylation; positive regulation of protein complex assembly; positive regulation of protein import into nucleus, translocation; positive regulation of tyrosine phosphorylation of STAT protein; protein import into nucleus, translocation; regulation of insulin secretion; response to virus
Disease: Aplastic Anemia; Hepatitis C Virus, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To; Tuberous Sclerosis 2
Reference #:  P01579 (UniProtKB)
Alt. Names/Synonyms: IFG; IFI; IFN-gamma; IFNG; Immune interferon; Interferon gamma; interferon, gamma
Gene Symbols: IFNG
Molecular weight: 19,348 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
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