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Protein Page:

FLOT1 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECM29. Belongs to the band 7/mec-2 family. Flotillin subfamily. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6p21.33
Cellular Component: apical plasma membrane; basolateral plasma membrane; caveola; cell-cell adherens junction; cortical actin cytoskeleton; cytoplasmic vesicle; early endosome; endosome; flotillin complex; focal adhesion; integral to membrane; intercellular junction; lamellipodium; lipid raft; lysosomal membrane; membrane; microtubule organizing center; plasma membrane; signalosome; uropod
Molecular Function: protease binding; protein binding; protein heterodimerization activity
Biological Process: dsRNA transport; extracellular matrix disassembly; lipid raft formation; positive regulation of cytokine production; positive regulation of endocytosis; positive regulation of heterotypic cell-cell adhesion; positive regulation of interferon-beta production; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding; positive regulation of skeletal muscle development; positive regulation of synaptic transmission, dopaminergic; positive regulation of toll-like receptor 3 signaling pathway; protein homooligomerization; protein stabilization; regulation of receptor internalization; regulation of toll-like receptor 4 signaling pathway
Reference #:  O75955 (UniProtKB)
Alt. Names/Synonyms: FLOT1; flotillin 1; Flotillin-1; integral membrane component of caveolae
Gene Symbols: FLOT1
Molecular weight: 47,355 Da
Basal Isoelectric point: 7.08  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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