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NRP1 The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Belongs to the neuropilin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 10p11.22
Cellular Component: axon; cell soma; cell surface; cytoplasmic vesicle; cytosol; early endosome; extracellular space; focal adhesion; growth cone; integral component of membrane; neurofilament; plasma membrane; receptor complex
Molecular Function: coreceptor activity; cytokine binding; growth factor binding; GTPase activator activity; heparin binding; metal ion binding; protein binding; semaphorin receptor activity; vascular endothelial growth factor-activated receptor activity
Biological Process: actin cytoskeleton reorganization; angiogenesis; artery morphogenesis; axon extension involved in axon guidance; axon guidance; axonal fasciculation; branching involved in blood vessel morphogenesis; branchiomotor neuron axon guidance; cell migration during sprouting angiogenesis; cell-cell signaling; dendrite development; endothelial cell migration; facial nerve structural organization; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; hepatocyte growth factor receptor signaling pathway; integrin-mediated signaling pathway; negative regulation of axon extension involved in axon guidance; negative regulation of neuron apoptosis; nerve development; neuron migration; organ morphogenesis; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; positive regulation of axon extension involved in axon guidance; positive regulation of endothelial cell proliferation; positive regulation of filopodium formation; positive regulation of focal adhesion assembly; positive regulation of GTPase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of stress fiber formation; regulation of Cdc42 protein signal transduction; response to wounding; retinal ganglion cell axon guidance; signal transduction; sprouting angiogenesis; substrate-dependent cell migration, cell extension; trigeminal nerve structural organization; vascular endothelial growth factor receptor signaling pathway; vestibulocochlear nerve structural organization
Reference #:  O14786 (UniProtKB)
Alt. Names/Synonyms: BDCA4; CD304; DKFZp686A03134; DKFZp781F1414; neuropilin 1; Neuropilin-1; NP1; NRP; NRP1; transmembrane receptor; Vascular endothelial cell growth factor 165 receptor; VEGF165R
Gene Symbols: NRP1
Molecular weight: 103,134 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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