a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors Note: This description may include information from UniProtKB.
Protein type: Alk family; EC 18.104.22.168; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Cellular Component: extracellular exosome; integral component of plasma membrane; intracellular; plasma membrane; protein complex
Molecular Function: ATP binding; identical protein binding; NF-kappaB-inducing kinase activity; protein binding; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: activation of MAPK activity; adult behavior; cell proliferation; hippocampus development; neuron development; NIK/NF-kappaB signaling; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of NF-kappaB transcription factor activity; protein autophosphorylation; regulation of apoptosis; regulation of cell proliferation; regulation of dopamine receptor signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway