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SLC1A4 Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 2p14
Cellular Component: cell surface; integral to plasma membrane; intermediate filament; membrane; plasma membrane
Molecular Function: amino acid transmembrane transporter activity; chloride channel activity; L-alanine transmembrane transporter activity; L-cystine transmembrane transporter activity; L-glutamine transmembrane transporter activity; L-proline transmembrane transporter activity; L-serine transmembrane transporter activity; L-threonine transmembrane transporter activity
Biological Process: amino acid transport; cognition; glutamine transport; L-alanine transport; L-cystine transport; L-serine transport; proline transport; threonine transport
Disease: Spastic Tetraplegia, Thin Corpus Callosum, And Progressive Microcephaly
Reference #:  P43007 (UniProtKB)
Alt. Names/Synonyms: Alanine/serine/cysteine/threonine transporter 1; ASCT-1; ASCT1; glutamate/neutral amino acid transporter; Neutral amino acid transporter A; SATT; SLC1A4; solute carrier family 1 (glutamate/neutral amino acid transporter), member 4; Solute carrier family 1 member 4
Gene Symbols: SLC1A4
Molecular weight: 55,723 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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